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Publication Topic: FDA

Public Comment | Considerations for the use of the Plausible Mechanism Framework to Develop Individualized Therapies that Target Specific Genetic Conditions with Known Biological Cause

Public Comment | Immunology and Microbiology Devices; Reclassification of Nucleic Acid-Based Test Systems for Use with a Corresponding Approved Oncology Therapeutic Product

White Paper | Assessing Contribution Of Effect (COE) In Oncology Combination Therapies Lessons Learned To Inform And Optimize Future Registrational Trial Designs

Public Comment | Oncology Therapeutic Radiopharmaceuticals: Dosage Optimization During Clinical Development Guidance for Industry

Public Comment | FDA CBER OTP Public Listening Meeting – Leveraging Knowledge for Facilitating the Development and Review of Cell and Gene Therapies

Public Comment | Development of Cancer Drugs for Use in Novel Combination – Determining the Contribution of the Individual Drugs’ Effects

Public Comment | FDA’s Considerations for Generating Clinical Evidence from MRCTs

Peer Review | Companion Diagnostic FDA Review Flexibilities: An Assessment of CDx for NSCLC to Support Aligned Approaches for Validation

Public Comment | Considerations for the Use of Artificial Intelligence to Support Regulatory Decision-Making for Drug and Biological Products

Public Comment | Request for Information on the Development of an Artificial Intelligence (AI) Action Plan Ensuring Efficient and Innovative Regulatory Approaches for AI in Drug Development

The integration of Artificial Intelligence (AI) and Machine Learning (ML) into drug development and diagnostics presents unprecedented opportunities to enhance patient care, streamline drug discovery, and improve the accuracy of diagnosis and treatment selection. However, these technologies may require a new regulatory paradigm, particularly given their adaptive nature. To ensure safety, efficacy, and reliability, regulatory…