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Publication Project: TMB Harmonization

Poster | 2018 SITC Annual Meeting | In Silico Assessment of Variation in TMB Quantification Across Diagnostic Platforms: Phase 1 of the Friends of Cancer Research Harmonization Project

Poster | 2019 ASCO Annual Meeting | TMB Standardization by Alignment to Reference Standards

Peer Review | Aligning tumor mutational burden (TMB) quantification across diagnostic platforms: phase II of the Friends of Cancer Research TMB Harmonization Project

Background Tumor mutational burden (TMB) measurements aid in identifying patients who are likely to benefit from immunotherapy; however, there is empirical variability across panel assays and factors contributing to this variability have not been comprehensively investigated. Identifying sources of variability can help facilitate comparability across different panel assays, which may aid in broader adoption of…

Peer Review | Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms